Protocol for Prevention and Control of COVID-19 by National Health Commission, China

National Health Commission of the People’s Republic of China

To prevent and control COVID-19, the illness caused by the novel coronavirus 2019-nCoV, ensure “early detection, early reporting, early isolation, and early treatment,” prevent further spread of the
outbreak, reduce the rate of infection, improve treatment and cure rates, reduce the case fatality rate,
protect people’s safety and health, and maintain social stability, the Novel Coronavirus Pneumonia Prevention
and Control Protocol, Edition 5, has now been revised and renamed the Protocol for Prevention and Control of
COVID-19, Edition 6. This update is in accordance with the policy that COVID-19 is classified as a
notifiable Category B infectious disease but regulated as a Category A infectious disease. The protocol update
is based on the evolution of the epidemic across the country and research advances, and it will support the
implementation of evidence-based practices with tailored and specific approaches for different regions of
the country and stages in disease prevention and control.


To prevent and control COVID-19 through provision of guidance of local efforts to detect and
report COVID-19 cases and clusters in a timely manner, conduct epidemiological investigations and
outbreak responses, and standardize management of close contacts.
Etiology and Epidemiological Characteristics

The novel coronavirus, 2019-nCov, is a β-type coronavirus, but its genetic characteristics are

significantly different from SARS-CoV and MERS- CoV, the viruses that cause SARS and MERS,

respectively. The 2019-nCoV is sensitive to ultraviolet rays and heat and can be killed by heating for 30
minutes at 56 °C; lipid solvents such as ether, 75% ethanol, chlorine-containing disinfectants, peracetic
acid, and chloroform can also inactivate the virus. Based on current epidemiological survey and research
results, the incubation period is 1–14 days and generally in the range of 3–7 days. The main source of  infection is COVID-19 patients, but asymptomatic individuals infected with 2019-nCoV may also infect
others. The main modes of transmission are via droplets and direct contact. The possibility of aerosol
transmission exists in relatively closed settings with exposure to high concentrations of aerosol for a long
period of time. Other transmission routes need further investigation. Virtually the entire population is
susceptible to 2019-nCoV infection.

Surveillance Case Definitions

Suspected Cases

The definition considers both epidemiological history and clinical manifestations:
Epidemiological history
1. History of travel to or residence in Wuhan and its surrounding areas, travel to other communities in
China where cases have been reported, or travel to other countries/regions with severe outbreaks outside
China within 14 days prior to the onset of the disease;
2. Contact with an individual infected with 2019- nCoV (who tested positive with a nucleic acid test) within 14 days prior to the onset of the disease;
3. Contact with patients with fever or respiratory
symptoms from Wuhan, Wuhan’s surrounding areas, communities where confirmed COVID-19 cases have
been reported, or from other countries/regions with severe outbreaks outside China within 14 days before
the onset of the disease; or
4. Clustered cases (two or more cases with fever and/or respiratory symptoms in a small area such as in
families, offices, schools, workplaces, and other gatherings within 14 days).
Clinical manifestations
1. Fever and/or respiratory symptoms;

2. Radiographic imaging consistent with COVID-
19 pneumonia;

3. Normal or decreased WBC count, or normal or decreased lymphocyte count in the early stages of
A suspected case is defined by having any of the epidemiological history criteria plus any two clinical
manifestations or by having all three clinical manifestations if there is no clear epidemiological

Confirmed Cases

Suspected cases with one of the following etiological or serological pieces of evidence:
1. Real-time fluorescent RT-PCR positive result for 2019-nCoV nucleic acid;
2. Viral genetic sequence that is highly homologous to 2019-nCoV;
3. 2019-nCoV virus-specific IgM and IgG detectable in serum, 2019-nCoV virus-specific IgG is
detectable, or there is at least a 4-fold increase in IgG between paired acute and convalescent sera.

Asymptomatic Infected Persons
Asymptomatic individuals with etiological detection of 2019-nCoV in respiratory specimens or specific IgM
detected in serum. These individuals may be found through tracing of close contacts, investigation of
clusters, and tracing of sources of infection. Clusters of Cases

Clusters of cases refer to 2 or more confirmed

COVID-19 cases or asymptomatic 2019-nCoV- infected persons in a small area such as in families,offices, schools, workplaces, and other gatherings within a 14-day period, in which there exists the
possibility of human-to-human transmission or common exposure.

Close Contacts

People who had unprotected, close contact with a confirmed or suspected case within two days prior to illness onset or with an asymptomatic 2019-nCoV- infected person within two days before obtaining

clinical samples from the asymptomatic infected

Prevention and Control Measures

Precision Prevention and Control Tailored to Specific Areas and Levels
In accordance with the Law of the People’s Republic of China on the Prevention and Treatment of Infectious
Diseases and the Regulations on Emergency Response to Public Health Emergencies, precise, tailored prevention
and control measures are to be implemented for different regions and at different levels. Epidemic risk level shall be assessed for each county/district (as a unit) based on its demographic and epidemiological situation, and appropriate prevention and control strategies shall be determined. In low-risk areas, the strategy is to “strictly prevent importation”. This includes strengthening tracking and management of people coming in from areas with
severe outbreaks and high-risk areas and enhancing health monitoring and services. Fever clinics should
strengthen monitoring, detection, and reporting of outpatients with fever, and the CDCs should conduct
timely epidemiological investigations and tracking and careful management of close contacts. The government
should provide guidance to both urban and rural communities, government agencies, enterprises, and
public institutions to strictly implement community prevention and control measures, improve
environmental hygiene, and promote disease prevention knowledge and skills to the general public.
In medium-risk areas, the strategy is “to prevent importation and stop local transmission”. This
includes the measures for low-risk areas, augmented with preparation for medical treatment, personnel,
materials, and venues required for disease prevention and control efforts, and isolated medical observation
and management of close contacts. School classrooms, building units, factory workplaces, and workplace
offices will serve as the smallest units of regulation. Resources, such as personnel for prevention and
control and tailored measures, can be identified and located based on a case-by-case review, epidemiological
investigation, and epidemic situational analysis. Townships, streets, and urban and rural communities
without confirmed cases may implement prevention and control measures of low-risk areas.
In high-risk areas, the strategy is “to stop local transmission, prevent exportation, and implement
strict prevention and control measures”. In addition to measures for medium-risk areas, this strategy involves
stopping activities involving gatherings of people and implementing regional traffic controls—with approval
and in accordance with law and procedures. Every county should conduct comprehensive screenings of
patients with fever; admit and manage in a timely manner suspected cases, confirmed cases, and
asymptomatically-infected patients; and isolate and place close contacts under medical observation.
Disinfection shall be conducted in sites with community transmission or clustered outbreaks in urban residential areas or rural villages, and control measures shall be taken to restrict the gathering, entry, and exit of people from the above sites. It is essential to conduct dynamic research and analysis, adjust risk levels in a timely manner, and reduce emergency response levels or terminate emergency responses after the case numbers decline steadily and the risk of epidemic spread is effectively controlled.

Early Detection

Healthcare facilities at all levels should raise their awareness of diagnosing and reporting COVID-19
cases. For individuals with respiratory symptoms such as fever and dry cough and digestive tract symptoms
such as diarrhea of unknown cause, their epidemiological history should be assessed, and expert,
joint consultations arranged during the time ofspecimen collection and testing.
Primary level organizations or employers should put great effort in screening people who travelled to or
resided in Wuhan and its surrounding areas within 14 days, people who travelled to or resided in
communities where confirmed cases have been reported, and people who have respiratory symptoms,
fever, chills, fatigue, diarrhea, conjunctival congestion, or other symptoms consistent with COVID-19 illness.
These individuals are key risk groups for screening, and their clinical sampling and testing should be performed
by professional institutions. Existing surveillance networks for pneumonia of
unknown etiology (PUE), influenza-like illness (ILI), and hospitalized severe, acute, respiratory illness
(SARI) should be employed to strengthen etiological surveillance.

Port health quarantine should be strengthened by strictly implementing temperature monitoring and medical inspection at inbound and outbound ports. For people with respiratory symptoms such as fever
and dry cough and digestive tract symptoms such as diarrhea, epidemiological investigation and medical
screening should be conducted, and specimens collected and pathogenic testing performed
The health status of close contacts should be monitored. Patients with respiratory symptoms such as
fever and dry cough and digestive tract symptoms such as diarrhea should be transferred in a timely manner to
the designated healthcare facilities with their specimens already collected and pathogenic testing completed.

Early Reporting

Case reporting. When suspected cases, confirmed cases, or asymptomatically-infected individuals are
identified, healthcare facilities at all levels and of all types should report the cases immediately via the
online direct reporting system. CDCs, upon receivin a report, shall conduct an investigation immediately,
verify the report, and complete a three-level confirmation and review within two hours in the
online direct reporting system. Healthcare facilities without online direct reporting capacity should make a
prompt report to the local county/district CDC and send a notifiable disease report card within two hours.
The local county/district CDC should make an online direct report upon receiving such a notification and
ensure the accuracy of all information.

Updating reports. Once suspected cases are confirmed or ruled out, the information should be
updated in a timely manner. If previously asymptomatic but infected persons develop clinical
manifestations, they should reclassified as “confirmed cases” in a timely manner. “Clinical severity” of all
cases should be updated with the progression of illness, with the most severe condition of the case as its final
severity designation. For individuals who died of COVID-19, the date of death should be recorded
within 24 hours.
When reporting asymptomatically-infected cases, the “collection date of a positive specimen” should be used
as the “date of onset”, and the “positive detection date” should be used as the “date of diagnosis”. If an
“asymptomatically-infected person” has been updated to a “confirmed case”, the “date of onset” should be
the date at which clinical symptoms appeared.

Reporting of emergency events. According to the requirements of the National Public Health Emergency
Response Contingency Plan and the National Public Health Emergency Related Information Reporting and

Management Rules (Trial Edition), the index COVID- 19 confirmed case or cluster in a county/district should be reported within two hours by the local CDC in the jurisdiction through the online direct reporting system for public health emergencies. The emergency level can be initially categorized as “unclassified” and should be
updated in a timely manner based on investigation findings and assessments.

Early Isolation

Case management. Suspected and confirmed cases should be isolated and treated in designated healthcare

facilities. Suspected cases should be isolated and treated in single rooms and can be ruled out as a suspected
case following 2 consecutive negative virus nucleic acid tests with at least a 24-hour interval between samplings
and negative IgM and IgG tests 7 days after onset of isolation.

Management after discharge. After a patient reaches discharge criteria and is discharged, the patients should
undergo a 14-day isolation and have their health status continuously monitored throughout the 14 days.
When possible, provincial-level administrative divisions are encouraged to strengthen follow-up
observation of discharged patients and testing of their respiratory specimens; those testing positive should be
put in centralized isolation for medical observation with their information submitted to China CDC.

Management of asymptomatic infected persons. Asymptomatic infected persons should be put undercentralized isolation for 14 days. Those testing negative with two consecutive virus nucleic acid tests (with at least 24-hour interval between samplings) can be released from isolation.

Early Treatment

Healthcare facilities at all levels and of all types should transfer suspect cases to designated hospitals in
a timely manner. Designated hospitals will be well prepared for case treatment in terms of personnel,
medicines, facilities, equipment, and personal protective equipment and will provide treatment
according to the most up-to-date COVID-19 diagnosis and treatment protocol. Efforts should be made to
ensure that “all in need are tested, admitted, treated, and isolated” in order to improve admission and cure
rates and to reduce infection and case fatality rates.

Epidemiological Investigation
Case investigation. The county/district CDC, upon receiving a report, should complete an epidemiological
investigation of cases and asymptomatically-infected persons within 24 hours. The investigation should be
conducted in accordance with requirements set out in the Guidelines for COVID-19 Epidemiological Investigation issued by China CDC. Tracing and registration of close contacts should be conducted

following requirements in the Guidelines for COVID- 19 Close Contact Management, and for suspected cases, the patient’s basic information and his or her close contacts should be registered.
Cluster investigation. The county/district CDC should conduct immediate investigation of suspected
clusters identified in the online-reported information and case investigation findings, following requirements
set out in the Guidelines for COVID-19  Epidemiological Investigation, as issued by China CDC.

Information reporting. The county/district CDC, upon completion of a case investigation of a confirmed
case or asymptomatically-infected person or an investigation of a suspected cluster, should submit the
case investigation form and investigation report to the online reporting system in a timely manner.

Close Contact Tracing and Management
Tracing and management of close contacts are organized and implemented by the county/district
health authorities along with other relevant departments. Close contacts are to be put under
centralized isolation and medical observation; if this is not feasible, home isolation and medical observation
can be used instead. Close contacts should be monitored at least twice a day, recording their body
temperature and recording whether they have respiratory symptoms such as fever and dry cough or
digestive tract symptoms such as diarrhea. The medical observation period for close contacts is 14 days after
the last unprotected contact with a case or with an asymptomatic infected person. If a suspected case is
ruled out, his or her close contacts can be removed from medical observation in accordance with
requirements set out in the Guidelines for COVID-19 Close Contact Management issued by China CDC.

Specimen Collection and Lab Testing

Healthcare facilities receiving COVID-19 cases should collect relevant clinical specimens in a timely
manner. Laboratories testing specimens (including eligible healthcare facilities, CDCs, or third-party labs)
should report test results within 12 hours. Specimen collection, transportation, storage, and testing should
be conducted strictly in accordance with the requirements set out in the Technical Guidelines for
COVID-19 Laboratory Testing issued by China CDC.
All original specimens from clusters of five or more COVID-19 cases should be sent to the China CDC
for verification and confirmation. Strengthen Prevention and Control

Measures Targeting Key Settings, Institutions, and Populations
It is essential to strengthen multi-sectoral, joint  prevention and control mechanisms to minimize public gathering activities and to implement measures such as ventilation, disinfection, and taking body
temperature in places with large population flows such as train stations, airports, ports, shopping malls, public
toilets, and closed vehicles such as cars, trains, and airplanes.
Health authorities should guide businesses to arrange for their employees to return to work in phases
and in logical groupings; to strictly conduct ventilation, disinfection, body temperature detection,
and other prevention and control activities; to provide employees with necessary personal protective
equipment and adopt strategies of partitioning operations and non-grouped dining; to effectively
reduce the concentrations of people; and to provide health education among migrant workers from rural
areas and strengthen temperature screening before returning to work. Once an abnormal situation is
detected, timely reporting, screening, and identification and response measures should be implemented to prevent people from leaving the area.
After schools and kindergartens reopen, health authorities shall provide health education, guide health
management of returning teachers and students, diligently ventilate and disinfect the classrooms, and
supervise implementation of prevention and control measures such as morning/afternoon checks, tracing
and registration of illness-related absences, an attendance. When an epidemic report is received,
epidemiological investigation, response measures, and guidance on disinfecting the affected area should be
urgently conducted.
For special institutions such as nursing homes, welfare institutions for the disabled, and places of
detention, the government should standardize management of personnel entry and exit, strict ventilation, daily cleaning and disinfection, and other health measures and strengthen personal protection measures, health monitoring, and daily management of incapacitated and semi-incapacitated individuals.
It is essential to implement health inspections and quarantine at ports for people entering China,
including enhancement of health management of people coming to China from countries and regions with serious epidemic situations. Activities include screening, investigation, diagnosis, treatment, and
medical observation of suspected cases, confirmed cases, and close contacts to strictly prevent cross-border spread of the epidemic.

Nosocomial Infection Control, Disinfection of Specific Settings, and
Personal Protection

Healthcare facilities should follow the requirements set out in the technical protocol for COVID-19
control and prevention in healthcare facilities to strictly implement nosocomial infection control and
prevention measures. This includes following the requirements in the Technical Guidelines for Disinfection in Healthcare Facilities and Hospital Air Purification Management Guidelines to clean and disinfect medical equipment, contaminated articles, surfaces, and floors, and to follow the Medical Waste Disposal Regulations and the Measures for Medical Waste Management in Healthcare Facilities for the disposal and management of medical wastes.
It is essential to implement effective disinfection  places used by COVID-19 patients and asymptomatic infected persons such as homes, isolation wards in healthcare facilities, transportation vehicles, and medical observation sites. It is essential to ensure effective protection of professionals who carry out epidemiological investigations, who work in isolation wards and medical observation sites, who transport cases, infected persons, or deceased persons, and who are involved in environmental cleaning and disinfection, specimen collection, or laboratory work. For relevant requirements, see Technical Guidelines for the Disinfection of Special Sites for COVID-19 and
Guidelines for Personal Protection of Specific Groups from COVID-19 issued by China CDC.

Public Education and Risk Communication

It is essential to disseminate knowledge about COVID-19 and its prevention and control. Health education and risk communication shall be enhanced for key populations to help guide the public on
personal protection to reduce possible contact or exposure. With progress in epidemic prevention and
control efforts and increasing understanding of COVID-19, health education strategies should be
updated and corresponding scientific public education should be organized in a timely manner. Activities
include public opinion monitoring, promptly response to concerns and questions of the public, and conducting risk communication on epidemic prevention and control.

Supportive Measures

Strengthening Organization and Leadership

Local governments should strengthen their leadership in response to the outbreak, ensure
availability of funding and materials, and implement prevention and control measures following the
principles of “prevention first, integration of prevention and treatment, scientific guidance, and timely treatment”.

Enhancing Joint Prevention and Control Efforts

Cross-sectoral information sharing and regular discussion and assessment of the epidemic trends
should be implemented and strengthened. Health authorities at all levels are responsible for overall
guidance of the epidemic control work. CDCs at all levels are responsible for case surveillance,
epidemiological investigations, close contact management, and laboratory testing. Healthcare
facilities at all levels are responsible for case finding and reporting; isolation, diagnosis, treatment, and clinical
management; and specimen collection and nosocomial infection control and prevention.

Strengthening Capacity Building
Technical training of health professionals in medical and health facilities on COVID-19 with a focus on
proactive prevention first shall be implemented. Strengthening scientific research and giving full play to
the role of information technology in the prevention and control of infectious diseases is essential, as is
conducting careful investigations on COVID-19 transmission dynamics, clinical features, and strategy
assessment to provide scientific evidence to optimize prevention and control strategies. The use of
traditional Chinese medicine in the prevention and treatment of infectious diseases is encouraged and


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